There are eleven different weapons available in the game - five for Leon and six for Claire. In this guide, you will find out where to find them.
Leon's weapon
Matilda
Leon's main weapon in Resident Evil 2, which will be with you throughout the campaign.
Shotgun W-870
Lies in the weapon locker on the first floor in the security cell. The Keycard is located on the second floor, on the table in the art room.
Lightning Hawk Magnum Pistol
First, go through the level in the parking lot and get the Heart Key (Claire) or the Club Key (Leon). Now go to the library on the second floor and take the red book from the table. Then go to the art room and find a statue with a broken arm - put the book in your hand and place it on the statue. You will receive a scepter - examine and turn it to get a red ruby.
Go to the interrogation / observation room and find the casket. Pair it with a ruby and you will receive the STARS badge. Examine it and you will receive a USB stick: use it on the computer in the STARS office to open the weapons cabinet. After you grab the weapon, grab the STARS badge, as it will come in handy for unlocking pistol upgrades.
Chemical flamethrower
Head to the Lower Sewers and go through the Lower Waterway. You will find yourself in the Pantry, where there will be a locked weapon locker and the Queen's plug. Insert the latter into the socket, go into the opened door and go upstairs. Here take the King's plug and use it to open the cabinet.
Rocket launcher
An anti-tank rocket launcher is given to Leon at the very end of the game to destroy the Super Tyrant.
M19 Pistol (Walkthrough B)
After you start replaying the game, go to the security room at the police station and take this weapon next to the storage box.
Claire's weapon
SLS 60
Claire's starting weapon. A regular 6-round revolver that takes a long time to reload.
GM 79 grenade launcher
Acquired in the same way as Leon's W-870 shotgun.
Laser sight pistol JMB Hp3
Lying in the trunk of a police car in the underground police station. The car key is on the training ground, in a yellow box on the bench.
Submachine gun MQ 11
Acquired in the same way as Leon's Magnum Pistol.
Sparks
Can be obtained in the same way as Leon's Chemical Flamethrower.
Minigun
Given by Claire at the very end of the game for the boss fight.
Army Revolver Quick Reload (Walkthrough B)
After you start replaying the game, go to the security room at the police station and take this weapon next to the storage box.
Bonus weapon
Infinite Ammo Pistol
Beat the game with S-grade on Normal difficulty.
Infinite Ammo Submachine Gun
Beat the S-grade game on Hardcore mode.