The Poisonous Trail is one of the quests associated with finding treasure. You will need to collect a series of clues, and if you do everything right, you will receive a good reward.
First treasure
Enter the hut and look under the bed - there will be a treasure box.
Second treasure
Climb a small hill where you will find a lone tree with a hole in the base.
Third treasure
On the map, you will see a snake sign, which is also on the treasure map (this place is located between Van Horn and the first river east of Van Horn). Go to where the same symbol will be on earth.
Fourth treasure
Head to the Champs-Elysees and then walk under a small waterfall. Get down on the right side and keep walking right until you see a small tunnel. Go inside and go to the very end, and then look to the left. You will see a crack where the treasure will be.
You end up with four gold bars, each of which can be sold to a stolen dealer for $ 500 - a whopping $ 2000 in total.
Videos with the exact location of the treasures