Mission 1: A Long Day at Dunwall
The first safe is located on the house, on the left side of the road. When you follow a mission, watch out for a house with a rent sign. You will face several guards. Enter the house and you will find the first combination behind the painting.
Safe combination: 451
Awards:
Two Silver Ingots
Two Silver Ingots
Pistol
Mission 2: At World's End
You should move towards the southern part of the map near the Addermire station. To the right of the station entrance, you can find a shop. Looks from the inside at the Try to Open Me banner. The exact location of the safe will be marked nearby.
Safe combination: Random
Awards:
Bone Charm
Gold
Silver
Pistol
Pistol cartridges
In the same mission, you will find another safe in the overseer's office.
Safe combination: 573
Awards:
Rune
Silver
Whalebone
Mission 3: The Good Doctor
At the Addermere Institute, take the elevator to the second floor. Go to the lab to visit Vasco's office. The safe is next to the desk. We talk with the chief, who is on the stretcher, he will give you a combination to open the safe.
Safe combination: 183
Awards:
Vasco Magazine
Another safe is located in the lobby of the institute. You must go ahead and get to the balcony to find a large office. There is a second safe by the table.
Safe combination: 183
Awards:
Combat Sleep Dart Blueprint
Copper wire
Silver ingot
Mission 4: Mechanical Mansion
In this mission you will find a large building ahead, look for a station with a Council Map on the wall. There is a short passage on the left side. At the end you will find a building with several people. Go to the first floor and then enter the office to locate the safe. The combination from the safe is written on the glasses hidden behind the bottle. You will get two numbers. After adding them, rotate the wheel until it opens.
Safe combination: Random
Awards:
Regenter Book
Lucky Sphalerite
Two Silver Ingots
Mission 5: Royal Cabinet of Curiosities
You must reach the balcony of the old building, where you will meet many bloody flies. The safe combo will be available once you complete the Vendor Black Market side mission. You can find the shopkeeper near Megan Foster's location. The store owner will only allow you to enter the store after you have given him the Roseburrow prototype. Inside the store, you will find a note with a combination.
Safe combination: Random
Awards:
Silver dust
Five Silver Bars
Ammunition for the pistol
Pistol
Mission 6: Crack in the Universe
Safe at Stilton Mansion
The mansion is not guarded, so you can explore as much as you like. Go to the noble man's room and go down through the floor to reach the music room. Talk to Stilton and The Outsider (Alien) to get to the Clock.
The watch will allow you to switch between time periods. You can explore the mansion as it is, or go back three years to see how it was before. Of course, when you go back in time, the mansion will be guarded, but you can grab more items and find a safe.
In the past, the mansion has a locked boiler room with a safe inside.
You need to take the body of the wolfhound to the past and cremate it using the oven. After that, return to the present tense sef, and you will see the correct combination already applied to the safe.
Safe combination: 238
Awards:
Kono stellar tables
Black amulet
Silver ingot
Two fives
Mission 7: The Grand Palace
Ravina Boulevard
Walk to the high tree of the central part of the street, where there will be an electric gate. Turn to the wall and you will see a building on your left. Come in and go up the stairs. Then follow the corridor until you reach a closed door and a manhole in the wall. Use your abilities to get inside.
When you find the safe, turn around and go to the workshop. Take a look to the right and you will see a black and white photograph of a person near the vault. The code will be in the photo.
Safe combination: 123
Awards:
Pistol and cartridges for it
Gold and silver bars
Captain's safe
From the terrace, go to the throne room, then to the foyer with a round bench. Then go to the left corridor, and then to the captain's office.
You will find the code in the Duke's office, whose room will be under the suite. The combination is on the table to the left of the desktop.
Safe combination: Random
Awards:
gold bar
Two Silver Ingots
Rune